ESPGHAN: BINC Geneva organised a science symposium


ESPGHAN 2019: BINC Geneva organised the science symposium
“Human microbiota shift: consequences and opportunities”

The symposium was chaired by professor Paul Cotter and two science international key opinion leaders Prof. Jon A Vanderhoof and Professors Susan Prescott will give presentations relating to this topic:

Disorders Impacted by The Gut Microbiome, Opportunities for Microbiome Manipulation.

By Prof.Jon A Vanderhoof

The gut microbiome and its role in health and disease has become the topic of intense investigation over the past several years. Dramatic shifts in the microbiome of individuals in the westernized world have been observed since the age of industrialization. Along with these changes, we have seen changes in diet, sanitation, and living conditions. In association with these changes in lifestyle and microbial colonization of the human gastrointestinal tract, dramatic increase in diseases associated with altered immune function have also been observed.. In many cases, perturbations in the microbiome seem to be associated with the epidemiology of these disorders. Experimental evidence has suggested potential mechanistic links between the gut microbiome, the immune system, and to some extent the nervous system.  Consequently, the potential for manipulation of the microbiome through diet, prebiotics, probiotics, and fecal transplantation are being studied with increasing frequency and in some cases with interesting and promising results.

Probiotic Solutions to Dysbiotic Drift: the need for integrative ecological approaches for the health of Person, Place and Planet.

By Prof. Susan Prescott

The ecology of the early environment determines life-long health, including microbial diversity, nutrition, nature, social interactions and virtually everything in the wider ‘exposome’. Almost all of these factors impact immunity had have implications for all aspects of health and reliance to disease. In particular, the emergence of ‘microbiome science’ provides new evidence of vital relationships between biodiversity and health at every level. Allergy was the first discipline to link adverse changes in early life ecology with the epidemic of immune disease—with much wider implications for other systems. New perspectives of ecological interdependence connect personal and planetary health; the human health crisis cannot be separated from the social, political and economic ‘ecosystems’ otherwise driving ‘dysbiosis’ (life in distress) at every level. Changes in macroscale ecology—of food systems, lifestyle behaviours, socioeconomic disadvantage and environmental degradation—all impact the microbial systems which sit at the foundations of all ecosystems. While there is promise with supplement-based strategies (e.g. probiotics, prebiotics), it is essential to focus on upstream factors implicated in dysbiosis; including the health of wider environments, lifestyle, nature relatedness, and the social policies and practices which can facilitate or inhibit “dysbiotic drift”. This highlights the necessity for ambitious integrative approaches which not only define these interconnections, but capitalize on them to create novel, collaborative and mutualistic solutions to our vast interdependent global challenges.