The role of OPN in early life

You may have already heard about Osteopontin or OPN?

OPN is a protein, specifically a phosphorylated glycoprotein, that is found in body tissues including bone and body fluids such as human milk. It plays important roles in immune, brain and gut development during early life.

How?

OPN increases the proportion of circulating T cells and the balance between T1 and T2 which are essential for the removal of pathogens.Milk OPN passes the blood-brain barrier increasing brain OPN levels.

Milk OPN has also been shown to have an impact on the function of intestinal development in preclinical models;

Furthermore, OPN can also be found in colonic mucosa of supplemented mice, where it has a protective effect against colitis.

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OPN – Osteopontin