Publication
Comparative Structural and Compositional Analyses of Cow, Buffalo, Goat and Sheep Cream

Factors affecting milk and milk fraction composition, such as cream, are poorly understood, with most research and human health application associated with cow cream. In this study, proteomic and lipidomic analyses were performed on cow, goat, sheep and buffalo, bulk milk cream samples. Laser scanning microscopy was used to determine the composition, including protein, lipid […]

Publication
HMO’s: Shaping the infant gut microbiota and supporting health

Breast milk is the optimal nutrition for infants, and its composition has been shaped by thousands of years of human evolution in order to provide tailor-made nutrition and protection to the developing neonate, all at an energetic cost to the mother. Recent advances in analytical tools and the development and integration of omics technologies have […]

Publication
From lab bench to formulated ingredient: Characterization, production, and commercialization of human milk oligosaccharides

Human milk oligosaccharides (HMOs) are known to positively influence infant health. Extensive variation exists in the levels, diversity, and complexity of oligosaccharides in the milk of a lactating mother. Until recently, limited availability of HMOs hampered their use in clinical applications. Most HMOs are unique to human milk, and have proven difficult and expensive to […]

Publication
2′-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway

Psoriasis is a chronic immune-mediated inflammatory cutaneous disorder with Th17 cells and Th17-related cytokines playing an important role in its development. 2′-FL (2′-fucosyllactose), which makes up about 30% of all HMOs (human milk oligosaccharides) in blood type secretor positive maternal milk, plays an essential role in supporting aspects of immune development and regulation. To explore […]

Publication
A combination of 2┬┤-Fucosyllactose and Osteopontin attenuates 2,4-dinitrochlorobenzene (DNCB)-induced contact dermatitis murine model

Topical Area: Nutrition/Neonatal and preterm nutrition Objectives and Study: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that is often associated with skin barrier dysfunction leading to a higher frequency of bacterial and viral skin infections. The protective effect of breastfeeding against the development of AD and other allergic diseases is well accepted […]

Publication
Community driven metabolism of Human Milk Oligosaccharides by a consortia of Bifidobacteria spp.

Topical Area: Nutrition/The gut microbiome Objectives and Study: Bifidobacteria are associated with a host of health benefits and are the most widely used probiotics in humans. These bacteria are highly abundant in the intestinal microbiota of healthy breastfed infants. Infant-associated Bifidobacteria spp. include Bifidobacterium longum subsp. infantis, Bifidobacterium bifidum and Bifidobacterium breve. A key adaptation, […]

Publication
Interrogation of Human Milk Oligosaccharide Utilization Pathways in an Infant Bifidobacterial Community by integrated Genomics and Proteomics

Topical Area: Nutrition/The gut microbiome Objectives and Study: Bifidobacteria are associated with positive effects on human health. The influence of human milk oligosaccharides (HMO) on the growth of bifidobacteria is of increasing interest; however, the mechanisms involved in carbohydrate metabolism in a bifidobacterial community are not clearly understood. The aim of this study was to […]

Publication
Xiang Cohort Study: An association of breast milk composition with maternal BMI and infant growth during the first three months of life.

Topical Area: Nutrition/infant feeding Objectives: The aim of this study was to establish a mother and child cohort in the Chinese population and to investigate human milk (HM) composition and its relationship with infant growth and development during the first three months of life. Methods: 110 Chinese mother and infant pairs were included in this […]

Publication
Probiotics maintain intestinal secretory immunoglobulin A levels in healthy formula-fed infants: a randomised, double blind-controlled study

L.Xiao. et al.2019

Publication
Precision Nutrition and the Microbiome, Part II: Potential Opportunities and Pathways for commercialisation