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HMO’s : modeler le microbiote intestinal du nourrisson pour renforcer sa santé (En anglais)

Breast milk is the optimal nutrition for infants, and its composition has been shaped by thousands of years of human evolution in order to provide tailor-made nutrition and protection to the developing neonate, all at an energetic cost to the mother. Recent advances in analytical tools and the development and integration of omics technologies have […]

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Du laboratoire à la formulation: caractérisation, production et commercialisation des oligosaccharides du lait maternel (En anglais)

Human milk oligosaccharides (HMOs) are known to positively influence infant health. Extensive variation exists in the levels, diversity, and complexity of oligosaccharides in the milk of a lactating mother. Until recently, limited availability of HMOs hampered their use in clinical applications. Most HMOs are unique to human milk, and have proven difficult and expensive to […]

Publication
Le 2′-fucosyllactose inhibe le psoriasis induit chez la souris en régulant la réponse des cellules th17 via la voie de signalisation stat3.(En anglais)

Psoriasis is a chronic immune-mediated inflammatory cutaneous disorder with Th17 cells and Th17-related cytokines playing an important role in its development. 2′-FL (2′-fucosyllactose), which makes up about 30% of all HMOs (human milk oligosaccharides) in blood type secretor positive maternal milk, plays an essential role in supporting aspects of immune development and regulation. To explore […]

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Une combinaison de 2′-fucosyllactose et d’ostéopontine atténue la dermatite de contact induite par le 2,4-dinitrochlorobenzène (dncb)(En anglais)

Topical Area: Nutrition/Neonatal and preterm nutrition Objectives and Study: Atopic dermatitis (AD) is a common chronic inflammatory skin disease that is often associated with skin barrier dysfunction leading to a higher frequency of bacterial and viral skin infections. The protective effect of breastfeeding against the development of AD and other allergic diseases is well accepted […]

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Oligosaccharides du lait maternel et bifidobacteries spp. (En anglais)

Topical Area: Nutrition/The gut microbiome Objectives and Study: Bifidobacteria are associated with a host of health benefits and are the most widely used probiotics in humans. These bacteria are highly abundant in the intestinal microbiota of healthy breastfed infants. Infant-associated Bifidobacteria spp. include Bifidobacterium longum subsp. infantis, Bifidobacterium bifidum and Bifidobacterium breve. A key adaptation, […]

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Interrogation des voies d’utilisation des oligosaccharides du lait maternel  dans une communauté de bifidobactéries de nourrissons par génomique et protéomique intégrées (En anglais)

Topical Area: Nutrition/The gut microbiome Objectives and Study: Bifidobacteria are associated with positive effects on human health. The influence of human milk oligosaccharides (HMO) on the growth of bifidobacteria is of increasing interest; however, the mechanisms involved in carbohydrate metabolism in a bifidobacterial community are not clearly understood. The aim of this study was to […]

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Étude de la cohorte xiang : association de la composition du lait maternel avec l’indice de masse corporelle de la mère et la croissance du nourrisson pendant les trois premiers mois de la vie. (En anglais )

Topical Area: Nutrition/infant feeding Objectives: The aim of this study was to establish a mother and child cohort in the Chinese population and to investigate human milk (HM) composition and its relationship with infant growth and development during the first three months of life. Methods: 110 Chinese mother and infant pairs were included in this […]

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Les probiotiques maintiennent les niveaux d’immunoglobuline A sécrétoire intestinale chez les nourrissons en bonne santé nourris au lait maternisé (En anglais)

L.Xiao. et al.2019

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Nutrition et microbiome – Partie II : Opportunités potentielles et voies de commercialisation (En anglais)

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Precision Nutrition and the Microbiome, Part I: Current State of the Science